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Valentina RUSSO

Anatomy of the reproductive system - Prof. Valentina Russo - a.y. 2024/2025

Reproductive Biotechnologies - 1st year

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    General information about the course

    Prof. RUSSO Valentina

     

    Born: Napoli, 10th May 1971

    Nationality: Italian

    PROFESSIONAL AND ACADEMIC EXPERIENCE

    1996, Degree in Veterinary Medicine, University of Naples “Federico II”, Italy (110/110 cum laude).

    1996, Licence to practise the Veterinary Profession.

    July 1997-September 2001, Scientific Technician for Veterinary Anatomy, Faculty of Veterinary Medicine, University of Teramo.

    October 2001-2015, Academic Researcher in Veterinary Anatomy (SSD-VET/01), Faculty of Veterinary Medicine, University of Teramo

    October 2015-2023, Associate Professor in Veterinary Anatomy (SSD-VET/01), Faculty of Veterinary Medicine, University of Teramo

    April 2023-present, Full Professor in Veterinary Anatomy (SSD-VET/01), Faculty of Veterinary Medicine, University of Teramo

    ACADEMIC ASSIGNMENTS

    2004 - 2014, elected for two terms Representative of the researchers of the Faculty Council of Veterinary Medicine, University of Teramo

    2012 – present Prof. Russo is scheduled in the register of reviewers of the Ministry of Education University and Research

    2013 – 2016 Delegate of the Rector for the Orientation programme of the Faculty of Veterinary Medicine

    2017-2019 Member of the AQ Commission of the Master Degree Course in Reproductive Biotechnologies.

    2016-2017 Responsible for the didactic activity of the Lazio Region "Torno Subito" Project.

    2018- 2023 Vice-coordinator of the PhD Course in "Cellular and Molecular Biotechnology", University of Teramo.

    2019 - to date Member of the CPDS Commission of the Faculty of Biosciences.

    2023- present, Coordinator of the PhD Course in "Cellular and Molecular Biotechnology", University of Teramo.

    Prof. Russo has been a member of the committees for Doctorate courses and postdoctoral fellowship admission calls.

    FUNDED RESEARCH PROJECTS

    She is in national (FIRB-PRIN) and European (H2020-MSCA) funded research projects, the main ones:

    - Chief Advisory Board for ITN-EJD 2015-REP-BIOTECH Grant agreement ID: 675526

    - Head of research units in COFUND-DP-2015- REP-EAT Grant agreement ID: 713714.

    - PI of the H2020-MSCA-ITN-EJD-2020-P4 FIT project Grant agreement ID: 955685

    EDITORIAL ACTIVITY

    - She is Editorial member for the following scientific journals:

    Stem Cells International

    Journal of Animal Research and Veterinary Science

    BioMed Research International.

    - Prof. Russo is Guest Editor for several Special Issues for:

    Cells

    International Journal of Molecular Sciences

    -Reviewer of several articles for scientific journals with IF.

    RESEARCH INTERESTS

    The research carried out by Prof. Valentina Russo focuses on Reproductive Biology and, in recent years, on the study of amniotic stem cells in Livestock Mammals. In particular:

    1. A) BIOLOGY OF REPRODUCTION

    1) Study on the epigenetic and telomeric reprogramming and on chromatin remodelling during post-natal oogenesis and in in vitro grown oocytes.

    2) Evaluation of the existing correlation between ovarian follicle growth and angiogenesis of the follicular wall determined by the expression of the Vascular Endothelial Growth Factor (VEGF).

    3) Cryobiology applied to the oocyte.

    1. B) AMNIOTIC STEM CELLS AND REGENERATIVE MEDICINE.

    1) isolation, characterization and amplification of amniotic epithelial and fluid stem cells (AECs and AFCs).

    2) Evaluation of AFC and AEC in vitro differentiating ability, in particular, for the tenogenic differentiation using the co-culture technique.

    3) Assessment of AFC and AEC regenerative potential in allo and xeno- transplantation in experimentally induced tendon lesions in sheep and in equine superficial digital flexor tendon spontaneous defects.

    4) Study of AFC and AEC survival, mitotic and differentiative ability, and epigenic stability in vitro and in vivo.

    5) Development and fabrication of tendon biomimetic scaffolds.

    6) Tendon biomimetic scaffolds engineering with AECs and their biocompatibility, teno-differentiation and immunomodulatory testing.

     

    Publications

    Valentina Russo has published 193 papers in all of which 80 on international peer reviewed scientific journals with impact factor (Total citations = 1125, h-index = 22).

    https://scholar.google.it/citations?hl=it&user=ZOy0okEAAAAJ&view_op=list_works&sortby=pubdate

     

    Russo participated to national and international Congresses, also as invited speaker.

     

    TEACHING AND RESEARCH IN HIGHER EDUCATION (PhD programmes)

    2018- 2023 Vice-coordinator of the PhD Course in "Cellular and Molecular Biotechnology", University of Teramo.

    2023-present Coordinator of the PhD Course in "Cellular and Molecular Biotechnology", University of Teramo.

    XVIII – XXIII cycle member of the Academic Board of the Doctorate Course in "Biotechnology of Reproduction", University of Teramo.

    XXIV- XXXVII cycle member of the Academic Board of the Doctorate Course in "Cellular and Molecular Biotechnology", University of Teramo.

    Prof. Russo was tutor of several national and international PhD students.

     

    TEACHING

    2003 - 2010, 1st Level Degree Course in Animal Welfare and Protection: In “Comparative Anatomy of Domestic animals”

    Academic years from 2005-ongoing Interuniversity 2nd Level Degree Course in Reproductive Biotechnology, University of Teramo and University of Chieti – Pescara in “Structure and Physiology of the Reproductive Apparatus”

    Academic years from 2020-ongoing 2nd Level Degree Course in Advanced Biotechnologies in “Tissue Engineering”.

    Academic year 2008- 2009, Faculty of Agriculture, University of Teramo, 1st Level Degree Course Food Science and Technologies: in “Structure and Function of animal organisms”

    Academic year 2011-2012, One-Long Cycle 2nd Level Degree Course in Veterinary Medicine:

    in “Veterinary Anatomy and Histology”.

    Publications

    Valentina Russo has published 198 papers in all of which 89 on international scientific journals with impact factor.

    https://scholar.google.it/citations?user=ZOy0okEAAAAJ&hl=it&oi=sra  

    Barbara Barboni

    PERSONAL DETAILS

    Barbara Barboni
    Born in Bologna the June 26, 1964
    Mother of Iacopo from 1996
    E-Mail: bbarboni@unite.it

    ACADEMIC QUALIFICATIONS
    ° From 1986 to 1990 Internal student of the Animal Physiology Unit of the Faculty of Veterinary Medicine, University of Bologna
    ° 1990: Doctor in Veterinary Medicine cum laude, University of Bologna discussing an experimental thesis entitled "Developmental competence of oocytes matured and fertilized in vitro"
    ° 1993: PhD in Neuroendocrinology, University of Bologna

    BIBLIOMETRIC INDICATORS on Google Scholar
    h-index 32
    h-index last 10 years 21

    Total citation more than 3800


    SCIENTIFIC PUBLICATION ACTIVITY
    -Published more than 250 scientific manuscripts, 98 of those are inserted in PubMed Central and publisher web sites, 
    - Published more than 300 abstracts related to national and international meeting attendances 
    - Co-authors of ten scientific international books 

    ACADEMIC APPOINTMENTS
    ° 1993: Research in Veterinary Physiology, University of Teramo, Italy
    ° 1998: Associate Professor in Veterinary Physiology, University of Teramo, Italy
    ° From 1999: Full professor in Veterinary Physiology, University of Teramo

    ACADEMIC LEADERSHIP
    °2011-2015 Rector’s delegate for research planning, University of Teramo
    °From 2001 Chair of the Basic and applied bioscience Unit, Faculty of Veterinary Medicine, University of Teramo
    °2000-2013 and from 2016 Coordinator of the doctoral program in Molecular and Cellular Biotechnology    

    From 2014 Member of Interuniversity National Consortium of Bio-Oncology (CINBO) as MIUR member  

    INFO ABOUT THE COURSE

    OBJECTIVES OF THE COURSE

    • Knowledge and understanding: This module aims to provide an in-depth an in-depth understanding of the anatomy of the reproductive system, focusing on the relationship between the structure and function of the female reproductive system in domestic animals and humans. Using the animal model, the student will acquire the necessary techniques to assess reproductive structures; in particular, those of the ovaries and female gamete
    • Applying knowledge and understanding: After the course students shall be able to apply their knowledge, understanding and ability to solve problems within biotechnology of reproduction multidisciplinary contexts appled both in zootechnical field and in the medically assisted procreation
    • Making judgements: Making judgement are developed through independent and group activities requiring as an individual personal effort (self-evaluation tests) as the colleagues comparison (laboratory exercises).
    • Communication: After the course students shall develop a clearly communication by information and their conclusions, knowledge and underpinning rationale, ideas, problems and solutions of the topics covered at specialists and non-specialists. In particular, they will be able to present their conclusions on biotechnology issues in a logical, concise and rigorous modality and communicant by technical-scientific language.
    • Learning skills: Students are expected to develop learning skills to allow them continuousindependently studying. Students develop adequate capacity to skills deepening also in library materials consultation, databases access and other web information



    PREREQUISITE AND PREPARATORY

    • Prerequisite: Additional obligations of the course (citology)
    • Preparatory: There are no propedeuticity

    DUBLIN DESCRIPTORS FOR UNIT


    UNIT 1: Macroscopic anatomy of the female reproductive organs

    • Knowledge and understanding: The unit aims are describe gross anatomy and topographical rapports of the domestical animal and human female genital organs
    • Applying knowledge and understanding: Applying knowledge and understanding of comparative macroscopic anatomy and topography of the female reproductive system are used and applied to procedures execution in dissection performed in anatomical room
    • Making judgements: To be able to develop a critic approach
    • Communication: To elaborate and suggest structured concepts
    • Learning skills: Develop themes aimed for critical approach


    UNIT 2: Cellular/tissutal organization of the uterus and fallopian tubes

    • Knowledge and understanding: Study and analysis of the uterine tubes and the microscopic anatomy of the uterus in domestic animals and women as well as their interaction with female reproductive cycle and the environment
    • Applying knowledge and understanding: To recognize microscopic structural organization of the treated organs. Applying knowledge and understanding has developed with individual or group laboratory activities
    • Making judgements: To be able to develop a critic approach
    • Communication: To elaborate and suggest structured concepts
    • Learning skills: Develop themes aimed for critical approach


    UNIT 3: Microscopic anatomy of the structures contained within the gonad and the female gamete of domestic animals and women

    • Knowledge and understanding: Study, microscopic analysis and applied methodologies of the ovaries and the evaluation of the female gamete in domestic animals and women. The student will also have to know the correlation between the ovarian follicle growth state and their angiogenic network.
    • Applying knowledge and understanding: After the unit students must be able to apply their knowledge, understanding and ability to recognize the ovarian structures and the egg cell characteristics in the different growth phases. This ability shall be proved by solving operational questions that require skills in handling laboratory equipment and a methods/protocols good knowledge used in the microscopic study of the female reproductive glandular portion.
    • Making judgements: To be able to develop a critic approach
    • Communication: To elaborate and suggest structured concepts
    • Learning skills: Develop themes aimed for critical approach

    COURSE BOOKS

    Anatomia comparata dei Mammiferi domestici, Vol.IV

    • Author: Barone R
    • Edition: Edagricole, Bologna


    Istologia

    • Author: Monesi V
    • Edition: PICCIN, Padova


    The Ovary

    • Author: Adaghi EY, Leung CK
    • Edition: Raven Press, New York


    Microscopie in biologia e in medicina

    • Author: Scala C, Pasquinelli G, Cenacchi G
    • Edition: CLUEB, Bologna

    RESEARCH MATERIAL

    Colocalization of DNA Fragmentation and Caspase-3 Activation During Atresia in Pig Antral Follicles

    • Author: P. Berardinelli, V. Russo, A. Martelli, D. Nardinocchi, O. Di Giacinto, B. Barboni and M. Mattioli


    Influence of Seasonality on Mammals Reproduction

    • Author: Moreira MK, Rodrigues SA


    Modifications in Chromatin Morphology and Organization During Sheep Oogenesis

    • Author: VALENTINA RUSSO, ALESSANDRA MARTELLI, PAOLO BERARDINELLI, ORIANA DI GIACINTO, NICOLA BERNABO` , DONATELLA FANTASIA, MAURO MATTIOLI, AND BARBARA BARBONI


    Spatio-temporal analysis of vascular endothelial growth factor expression and blood vessel remodelling in pig ovarian follicles during the periovulatory period

    • Author: A Martelli, P Berardinelli, V Russo, A Mauro, N Bernabò, L Gioia, M Mattioli and B Barboni


    Blood vessel remodeling in pig ovarian follicles during the periovulatory period: an immunohistochemistry and SEM-corrosion casting study

    • Author: Alessandra Martelli, Maria Grazia Palmerini, Valentina Russo, Carlo Rinaldi, Nicola Bernabò, Oriana Di Giacinto, Paolo Berardinelli, Stefania Annarita Nottola, Guido Macchiarelli and Barbara Barboni

    INTERMEDIATE TESTS


    INTERMEDIATE TEST 1

    • Reference unit: unit 1
    • Date: 
    • Type of test: multiple choice test


    INTERMEDIATE TEST 2

    • Reference unit: unit 2
    • Date: 
    • Type of test: multiple choice test


    INTERMEDIATE TEST 3

    • Reference unit: unit 3
    • Date: 
    • Type of test: multiple choice test

    FINAL EXAM

    • Reference unit: unit 1, 2, 3
    • Date: 
    • Type of test: oral examination

    EVALUATION
    Final testing has performed with oral examinations

     

     

  • Unit 1: macroscopic anatomy of the female reproductive organs

    Macroscopic anatomy and topographic relationships of the female reproductive organs

  • Unit 2: cellular/tissutal organization of the ovary

    microscopic anatomy


  • Unit 3: microscopic anatomy of the uterine tubes and uterus



  • Program and bibliografy

  • Topic 5

  • Topic 6

  • Topic 7

  • Topic 8

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